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5314],[119,15315,119,15319],[119,15320,119,15324],[119,15325,119,15329],[119,15330,119,15334],[119,15335,119,15339],[119,15340,119,15344],[119,15345,119,15349],[119,15350,119,15354],[119,15355,119,15359],[119,15360,119,15364],[119,15365,119,15369],[119,15370,119,15374],[119,15375,119,15379],[119,15380,119,15384],[119,15385,119,15389],[119,15390,119,15394],[119,15395,119,15399],[119,15400,119,15404],[119,15405,119,15409],[119,15410,119,15414],[119,15415,119,15419],[119,15420,119,15424],[119,15425,119,15429],[119,15430,119,15434],[119,15435,119,15439],[119,15440,119,15444],[119,15445,119,15449],[119,15450,119,15454],[119,15455,119,15459],[119,15460,119,15464],[119,15465,119,15469],[119,15470,119,15474],[119,15475,119,15479],[119,15480,119,15484],[119,15485,119,15489],[119,15490,119,15494],[119,15495,119,15499],[119,15500,119,15504],[119,15505,119,15509],[119,15510,119,15514],[119,15515,119,15519],[119,15520,119,15524],[119,15525,119,15529],[119,15530,119,15534],[119,15535,119,15539],[119,15540,119,15544],[119,15545,119,15549],[119,15550,119,15554],[119,15555,119,15559],[119,15560,119,15564],[119,15565,119,15569],[119,15570,119,15574],[119,15575,119,15579],[119,15580,119,15584],[119,15585,119,15589],[119,15590,119,15594],[119,15595,119,15599],[119,15600,119,15604],[119,15605,119,15609],[119,15610,119,15614],[119,15615,119,15619],[119,15620,119,15624],[119,15625,119,15629],[119,15630,119,15634],[119,15635,119,15639],[119,15640,119,15644],[119,15645,119,15649],[119,15650,119,15654],[119,15655,119,15659],[119,15660,119,15664],[119,15665,119,15669],[119,15670,119,15674],[119,15675,119,15679],[119,15680,119,15684],[119,15685,119,15689],[119,15690,119,15694],[119,15695,119,15699],[119,15700,119,15704],[119,15705,119,15709],[119,15710,119,15714],[119,15715,119,15719],[119,15720,119,15724],[119,15725,119,15729],[119,15730,119,15734],[119,15735,119,15739],[119,15740,119,15744],[119,15745,119,15749],[119,15750,119,15754],[119,15755,119,15759],[119,15760,119,15764],[119,15765,119,15769],[119,15770,119,15774],[119,15775,119,15779],[119,15780,119,15784],[119,15785,119,15789],[119,15790,119,15794],[119,15795,119,15799],[119,15800,119,15804],[119,15805,119,15809],[119,15810,119,15814],[119,15815,119,15819],[119,15820,119,15824],[119,15825,119,15829],[119,15830,119,15834],[119,15835,119,15839],[119,15840,119,15844],[119,15845,119,15849],[119,15850,119,15854],[119,15855,119,15859],[119,15860,119,15864],[119,15865,119,15869],[119,15870,119,15874],[119,15875,119,15879],[119,15880,119,15884],[119,15885,119,15889],[119,15890,119,15894],[119,15895,119,15899],[119,15900,119,15904],[119,15905,119,15909],[119,15910,119,15914],[119,15915,119,15919],[119,15920,119,15924],[119,15925,119,15929],[119,15930,119,15934],[119,15935,119,15939],[119,15940,119,15944],[119,15945,119,15949],[119,15950,119,15954],[119,15955,119,15959],[119,15960,119,15964],[119,15965,119,15969],[119,15970,119,15974],[119,15975,119,15979],[119,15980,119,15984],[119,15985,119,15989],[119,15990,119,15994],[119,15995,119,15999],[119,16000,119,16004],[119,16005,119,16009],[119,16010,119,16014],[119,16015,119,16019],[119,16020,119,16024],[119,16025,119,16029],[119,16030,119,16034],[119,16035,119,16039],[119,16040,119,16044],[119,16045,119,16049],[119,16050,119,16054],[119,16055,119,16059],[119,16060,119,16064],[119,16065,119,16069],[119,16070,119,16074],[119,16075,119,16079],[119,16080,119,16084],[119,16085,119,16089],[119,16090,119,16094],[119,16095,119,16099],[119,16100,119,16104],[119,16105,119,16109],[119,16110,119,16114],[119,16115,119,16119],[119,16120,119,16124],[119,16125,119,16129],[119,16130,119,16134],[119,16135,119,16139],[119,16140,119,16144],[119,16145,119,16149],[119,16150,119,16154],[119,16155,119,16159],[119,16160,119,16164],[119,16165,119,16169],[119,16170,119,16174],[119,16175,119,16179],[119,16180,119,16184],[119,16185,119,16189],[119,16190,119,16194],[119,16195,119,16199],[119,16200,119,16204],[119,16205,119,16209],[119,16210,119,16214],[119,16215,119,16219],[119,16220,119,16224],[119,16225,119,16229],[119,16230,119,16234],[119,16235,119,16239],[119,16240,119,16244],[119,16245,119,16249],[119,16250,119,16254],[119,16255,119,16259],[119,16260,119,16264],[119,16265,119,16269],[119,16270,119,16274],[119,16275,119,16279],[119,16280,119,16284],[119,16285,119,16289],[119,16290,119,16294],[119,16295,119,16299],[119,16300,119,16304],[119,16305,119,16309],[119,16310,119,16314],[119,16315,119,16319],[119,16320,119,16324],[119,16325,119,16329],[119,16330,119,16334],[119,16335,119,16339],[119,16340,119,16344],[119,16345,119,16349],[119,16350,119,16354],[119,16355,119,16359],[119,16360,119,16364],[119,16365,119,16369],[119,16370,119,16374],[119,16375,119,16379],[119,16380,119,16383],[120,2,120,4],[121,2,121,4],[122,2,122,4],[123,2,123,4],[124,2,124,4],[125,0,125,4],[126,2,126,4],[127,2,127,4],[128,2,128,4],[129,2,129,4],[130,2,130,4],[131,0,131,4],[132,2,132,4],[133,2,133,4],[134,2,134,4],[135,2,135,4],[136,2,136,4],[137,2,137,4],[138,2,138,4],[139,2,139,4],[140,2,140,4],[141,2,141,4],[142,2,142,4],[143,2,143,4],[144,2,144,4],[145,2,145,4],[146,2,146,4],[147,2,147,4],[148,2,148,4],[149,2,149,4],[150,2,150,4],[151,2,151,4],[152,0,152,4],[153,2,153,4],[154,2,154,4],[155,2,155,4],[156,2,156,4],[157,2,157,4],[158,2,158,4],[159,2,159,4],[160,2,160,4],[161,0,161,4],[162,2,162,4],[163,2,163,4],[164,2,164,4],[165,2,165,4],[166,2,166,4],[167,2,167,4],[168,0,168,4],[169,2,169,4],[170,2,170,4],[171,2,171,4],[172,2,172,4],[173,2,173,4],[174,2,174,4],[175,2,175,4],[176,2,176,4],[177,2,177,4],[178,2,178,4],[179,2,179,4],[180,2,180,4],[181,2,181,4],[182,2,182,4],[183,2,183,4],[184,2,184,4],[185,2,185,4],[186,2,186,4],[187,2,187,4],[188,2,188,4],[189,2,189,4],[190,2,190,4],[191,2,191,4],[192,2,192,4],[193,2,193,4],[194,2,194,4],[195,2,195,4],[196,2,196,4],[197,2,197,4],[198,2,198,4],[199,2,199,4],[200,2,200,4],[201,2,201,4],[202,2,202,4],[203,2,203,4],[204,2,204,4],[205,2,205,4],[206,2,206,4],[207,2,207,4],[208,2,208,4],[209,0,209,4],[210,2,210,4],[211,2,211,4],[212,2,212,4],[213,2,213,4],[214,2,214,4],[215,2,215,4],[216,2,216,4],[217,2,217,4],[218,2,218,4],[219,2,219,4],[220,2,220,4],[221,2,221,4],[222,0,222,4],[223,2,223,4],[224,2,224,4],[225,2,225,4],[226,2,226,4],[227,2,227,4]],"merged_total":3446,"flags":["merged_cut"]}
["Summary of all the 212 features in the candidate feature set"]
["#","Feature Name","Description","Filter","Weighted"]
["PSI-BLAST-based Sequence Features"]
[1,"nal","Number of sequences in the alignment","All","No"]
[2,"naa","Number of amino acids in the aligned position","All","No"]
[3,"nwt","Number of wild-type amino acids in the aligned position","All","No"]
[4,"nmt","Number of mutant amino acids in the aligned position","All","No"]
[5,"rwt","Relative number of aligned wild-type amino acids","All","No"]
[6,"rmt","Relative number of aligned mutant amino acids","All","No"]
[7,"pwm","Position Weight Matrix score","All","No"]
[8,"nal_human","Number of sequences in the alignment","Human","No"]
[9,"naa_human","Number of amino acids in the aligned position","Human","No"]
[10,"nwt_human","Number of wild-type amino acids in the aligned position","Human","No"]
[11,"nmt_human","Number of mutant amino acids in the aligned position","Human","No"]
[12,"rwt_human","Relative number of aligned wild-type amino acids","Human","No"]
[13,"rmt_human","Relative number of aligned mutant amino acids","Human","No"]
[14,"pwm_human","Position Weight Matrix score","Human","No"]
[15,"nal_no_human","Number of sequences in the alignment","No Human","No"]
[16,"naa_no_human","Number of amino acids in the aligned position","No Human","No"]
[17,"nwt_no_human","Number of wild-type amino acids in the aligned position","No Human","No"]
[18,"nmt_no_human","Number of mutant amino acids in the aligned position","No Human","No"]
[19,"rwt_no_human","Relative number of aligned wild-type amino acids","No Human","No"]
[20,"rmt_no_human","Relative number of aligned mutant amino acids","No Human","No"]
[21,"pwm_no_human","Position Weight Matrix score","No Human","No"]
[22,"nal_1e-45","Number of sequences in the alignment","E-value < 10-45","No"]
[23,"naa_1e-45","Number of amino acids in the aligned position","E-value < 10-45","No"]
[24,"nwt_1e-45","Number of wild-type amino acids in the aligned position","E-value < 10-45","No"]
[25,"nmt_1e-45","Number of mutant amino acids in the aligned position","E-value < 10-45","No"]
[26,"rwt_1e-45","Relative number of aligned wild-type amino acids","E-value < 10-45","No"]
[27,"rmt_1e-45","Relative number of aligned mutant amino acids","E-value < 10-45","No"]
[28,"pwm_1e-45","Position Weight Matrix score","E-value < 10-45","No"]
[29,"nal_w","Number of sequences in the alignment","All","BLAST score"]
[30,"naa_w","Number of amino acids in the aligned position","All","BLAST score"]
[31,"nwt_w","Number of wild-type amino acids in the aligned position","All","BLAST score"]
[32,"nmt_w","Number of mutant amino acids in the aligned position","All","BLAST score"]
[33,"rwt_w","Relative number of aligned wild-type amino acids","All","BLAST score"]
[34,"rmt_w","Relative number of aligned mutant amino acids","All","BLAST score"]
[35,"pwm_w","Position Weight Matrix score","All","BLAST score"]
[36,"nal_human_w","Number of sequences in the alignment","Human","BLAST score"]
[37,"naa_human_w","Number of amino acids in the aligned position","Human","BLAST score"]
[38,"nwt_human_w","Number of wild-type amino acids in the aligned position","Human","BLAST score"]
[39,"nmt_human_w","Number of mutant amino acids in the aligned position","Human","BLAST score"]
[40,"rwt_human_w","Relative number of aligned wild-type amino acids","Human","BLAST score"]
[41,"rmt_human_w","Relative number of aligned mutant amino acids","Human","BLAST score"]
[42,"pwm_human_w","Position Weight Matrix score","Human","BLAST score"]
[43,"nal_no_human_w","Number of sequences in the alignment","No Human","BLAST score"]
[44,"naa_no_human_w","Number of amino acids in the aligned position","No Human","BLAST score"]
[45,"nwt_no_human_w","Number of wild-type amino acids in the aligned position","No Human","BLAST score"]
[46,"nmt_no_human_w","Number of mutant amino acids in the aligned position","No Human","BLAST score"]
[47,"rwt_no_human_w","Relative number of aligned wild-type amino acids","No Human","BLAST score"]
[48,"rmt_no_human_w","Relative number of aligned mutant amino acids","No Human","BLAST score"]
[49,"pwm_no_human_w","Position Weight Matrix score","No Human","BLAST score"]
[50,"nal_1e-45_w","Number of sequences in the alignment","E-value < 10-45","BLAST score"]
[51,"naa_1e-45_w","Number of amino acids in the aligned position","E-value < 10-45","BLAST score"]
[52,"nwt_1e-45_w","Number of wild-type amino acids in the aligned position","E-value < 10-45","BLAST score"]
[53,"nmt_1e-45_w","Number of mutant amino acids in the aligned position","E-value < 10-45","BLAST score"]
[54,"rwt_1e-45_w","Relative number of aligned wild-type amino acids","E-value < 10-45","BLAST score"]
[55,"rmt_1e-45_w","Relative number of aligned mutant amino acids","E-value < 10-45","BLAST score"]
[56,"pwm_1e-45_w","Position Weight Matrix score","E-value < 10-45","BLAST score"]
[57,"Entropy","Shannon's entropy for a given amino acid substitution (AAS) position"]
[58,"PSSM_Wild","PSSM (Position-Specific Scoring Matrix）score of wild-type amino acid at AAS position"]
[59,"PSSM_Mutant","PSSM score of mutant amino acid at AAS position"]
[60,"dPSSM","Difference between PSSM score of mutant and wild-type amino acids at AAS position"]
[61,"Percentage_Wild","Weighted percentage of wild-type amino acid at AAS position"]
[62,"Percentage_Mutant","Weighted percentage of mutant amino acid at AAS position"]
[63,"Position_Info","Position's information content"]
[64,"Entropy_RING","Shannon's entropy of a given AAS position obtained from RING software"]
["Gene-level Metrics"]
[65,"GDI","Gene Damage Index describing the cumulative mutational damage for each human protein-coding gene"]
[66,"RVIS","Residual Variation Intolerance Score assessing human genes' ability to tolerate common functional genetic variation in healthy individuals"]
["Substitution Matrix Scores"]
[67,"BLOSUM62","Score of AAS in BLOSUM62 matrix"]
[68,"Grantham","Score of physicochemical dissimilarities between amino acid in Grantham matrix"]
[69,"Miyata","Score of physicochemical dissimilarities between amino acid in Miyata matrix"]
["Differences of Physicochemical Properties"]
[70,"dF1","Difference between factor Ⅰ solution score (bipolar) of mutant and wild-type amino acids"]
[71,"dF2","Difference between factor Ⅱ solution score (secondary structure) of mutant and  wild-type amino acids"]
[72,"dF3","Difference between factor Ⅲ solution score (molecular size and volume) of mutant and wild-type amino acids "]
[73,"dF4","Difference between factor Ⅳ solution score (amino acid composition and codon usage) of mutant and wild-type amino acids"]
[74,"dF5","Difference between factor Ⅴ solution score (electrostatic charge) of mutant and wild-type amino acids"]
[75,"dVol","Difference between Grantham molecular volume of mutant and wild-type amino acids"]
[76,"dHP","Difference between Kyte-Doolittle hydropathy index of mutant and wild-type amino acids"]
[77,"dpI","Difference between Isoelectric point of mutant and wild-type amino acids"]
[78,"Abs_dF1","Absolute difference between factor Ⅰ solution score (bipolar) of mutant and wild-type amino acids "]
[79,"Abs_dF2","Absolute difference between factor Ⅱ solution score (secondary structure) of mutant and wild-type amino acids "]
[80,"Abs_dF3","Absolute difference between factor Ⅲ solution score (molecular size and volume) of mutant and wild-type amino acids"]
[81,"Abs_dF4","Absolute difference between factor Ⅳ solution score (amino acid composition and codon usage) of mutant and wild-type amino acids "]
[82,"Abs_dF5","Absolute difference between factor Ⅴ solution score (electrostatic charge) of mutant and wild-type amino acids "]
[83,"Abs_dVol","Absolute difference between Grantham molecular volume of mutant and wild-type amino acids "]
[84,"Abs_dHP","Absolute difference between Kyte-Doolittle hydropathy index of mutant and wild-type amino acids"]
[85,"Abs_dpI","Absolute difference between Isoelectric point of mutant and wild-type amino acids"]
["The Composition of Nearby Sequence"]
[86,"SeqCom_#Ala","Number of Ala based on a window of 19 amino acids"]
[87,"SeqCom_#Arg","Number of Arg based on a window of 19 amino acids"]
[88,"SeqCom_#Asn","Number of Asn based on a window of 19 amino acids"]
[89,"SeqCom_#Asp","Number of Asp based on a window of 19 amino acids"]
[90,"SeqCom_#Cys","Number of Cys based on a window of 19 amino acids"]
[91,"SeqCom_#Gln","Number of Gln based on a window of 19 amino acids"]
[92,"SeqCom_#Glu","Number of Glu based on a window of 19 amino acids"]
[93,"SeqCom_#Gly","Number of Gly based on a window of 19 amino acids"]
[94,"SeqCom_#His","Number of His based on a window of 19 amino acids"]
[95,"SeqCom_#Ile","Number of Ile based on a window of 19 amino acids"]
[96,"SeqCom_#Leu","Number of Leu based on a window of 19 amino acids"]
[97,"SeqCom_#Lys","Number of Lys based on a window of 19 amino acids"]
[98,"SeqCom_#Met","Number of Met based on a window of 19 amino acids"]
[99,"SeqCom_#Phe","Number of Phe based on a window of 19 amino acids"]
[100,"SeqCom_#Pro","Number of Pro based on a window of 19 amino acids"]
[101,"SeqCom_#Ser","Number of Ser based on a window of 19 amino acids"]
[102,"SeqCom_#Thr","Number of Thr based on a window of 19 amino acids"]
[103,"SeqCom_#Trp","Number of Trp based on a window of 19 amino acids"]
[104,"SeqCom_#Tyr","Number of Tyr based on a window of 19 amino acids"]
[105,"SeqCom_#Val","Number of Val based on a window of 19 amino acids"]
["Functional Regions of Interest"]
[106,"CA_BIND","AAS is in calcium binding region or not"]
[107,"DNA_BIND","AAS is in DNA-binding domain or not"]
[108,"NP_BIND","AAS is in nucleotide phosphate binding region or not"]
[109,"TRANSMEM","AAS is in membrane-spanning region or not"]
[110,"ZN_FING","AAS is in zinc fingers or not"]
[111,"Region_All","AAS is in {CA_BIND,DNA_BIND,NP_BIND,TRANSMEM,ZN_FING} or not"]
["Sequence Distance of Nearby Functional Sites"]
[112,"SeqDis_ACT_SITE","The least sequence distance between the AAS site and active sites"]
[113,"SeqDis_BINDING","The least sequence distance between the AAS site and chemical group binding sites"]
[114,"SeqDis_DISULFID","The least sequence distance between the AAS site and disulfide-bonded Cys"]
[115,"SeqDis_METAL","The least sequence distance between the AAS site and metal ion binding sites"]
[116,"SeqDis_All_Site","The least sequence distance between the AAS site and nearby functional sites mentioned above"]
["Structural Distance of Nearby Functional Sites"]
[117,"StruDis_ACT_SITE","The least structural distance between the AAS site and active sites"]
[118,"StruDis_BINDING","The least structural distance between the AAS site and chemical group binding sites"]
[119,"StruDis_DISULFID","The least structural distance between the AAS site and disulfide-bonded Cys"]
[120,"StruDis_METAL","The least structural distance between the AAS site and metal ion binding sites"]
[121,"StruDis_All_Site","The least structural distance between the AAS site and nearby functional sites mentioned above"]
["The Composition of Structural Contacting Neighbors"]
[122,"StruCom_#Ala","Number of Ala whose Ca atoms are within a 6.5 Å distance of the Ca atom in the wild-type amino acid where AAS occurs "]
[123,"StruCom_#Arg","Number of Arg whose Ca atoms are within a 6.5 Å distance of the Ca atom in the wild-type amino acid where AAS occurs "]
[124,"StruCom_#Asn","Number of Asn whose Ca atoms are within a 6.5 Å distance of the Ca atom in the wild-type amino acid where AAS occurs "]
[125,"StruCom_#Asp","Number of Asp whose Ca atoms are within a 6.5 Å distance of the Ca atom in the wild-type amino acid where AAS occurs "]
[126,"StruCom_#Cys","Number of Cys whose Ca atoms are within a 6.5 Å distance of the Ca atom in the wild-type amino acid where AAS occurs "]
[127,"StruCom_#Gln","Number of Gln whose Ca atoms are within a 6.5 Å distance of the Ca atom in the wild-type amino acid where AAS occurs "]
[128,"StruCom_#Glu","Number of Glu whose Ca atoms are within a 6.5 Å distance of the Ca atom in the wild-type amino acid where AAS occurs "]
[129,"StruCom_#Gly","Number of Gly whose Ca atoms are within a 6.5 Å distance of the Ca atom in the wild-type amino acid where AAS occurs"]
[130,"StruCom_#His","Number of His whose Ca atoms are within a 6.5 Å distance of the Ca atom in the wild-type amino acid where AAS occurs "]
[131,"StruCom_#Ile","Number of Ile whose Ca atoms are within a 6.5 Å distance of the Ca atom in the wild-type amino acid where AAS occurs "]
[132,"StruCom_#Leu","Number of Leu whose Ca atoms are within a 6.5 Å distance of the Ca atom in the wild-type amino acid where AAS occurs "]
[133,"StruCom_#Lys","Number of Lys whose Ca atoms are within a 6.5 Å distance of the Ca atom in the wild-type amino acid where AAS occurs "]
[134,"StruCom_#Met","Number of Met whose Ca atoms are within a 6.5 Å distance of the Ca atom in the wild-type amino acid where AAS occurs "]
[135,"StruCom_#Phe","Number of Phe whose Ca atoms are within a 6.5 Å distance of the Ca atom in the wild-type amino acid where AAS occurs "]
[136,"StruCom_#Pro","Number of Pro whose Ca atoms are within a 6.5 Å distance of the Ca atom in the wild-type amino acid where AAS occurs "]
[137,"StruCom_#Ser","Number of Ser whose Ca atoms are within a 6.5 Å distance of the Ca atom in the wild-type amino acid where AAS occurs "]
[138,"StruCom_#Thr","Number of Thr whose Ca atoms are within a 6.5 Å distance of the Ca atom in the wild-type amino acid where AAS occurs "]
[139,"StruCom_#Trp","Number of Trp whose Ca atoms are within a 6.5 Å distance of the Ca atom in the wild-type amino acid where AAS occurs "]
[140,"StruCom_#Tyr","Number of Tyr whose Ca atoms are within a 6.5 Å distance of the Ca atom in the wild-type amino acid where AAS occurs "]
[141,"StruCom_#Val","Number of Val whose Ca atoms are within a 6.5 Å distance of the Ca atom in the wild-type amino acid where AAS occurs "]
["Secondary Structure"]
[142,"SS_H","Whether the AAS occurs in a-helix"]
[143,"SS_I","Whether the AAS occurs in p-helix "]
[144,"SS_G","Whether the AAS occurs in 310 helix"]
[145,"SS_S","Whether the AAS occurs in bend"]
[146,"SS_T","Whether the AAS occurs in hydrogen bonded turn "]
[147,"SS_B","Whether the AAS occurs in isolated b-bridge"]
[148,"SS_C","Whether the AAS occurs in loop or its secondary structure is irregular"]
[149,"SS_E","Whether the AAS occurs in extended strand"]
["Network Topological Measures"]
[150,"Degree","Total number of connections for a given residue"]
[151,"Clustering_Coefficient","The tendency of the neighbors of a residue to interact with each other"]
[152,"Closeness_Centrality","Accessibility of a residue from all other residues connected to it"]
[153,"Betweenness_Centrality","The sum of the fraction of all-pairs shortest paths that pass through a given residue"]
[154,"NB_Max_Degree","Maximum degree value of the structural contacting neighbors for a given residue"]
[155,"NB_Mean_Degree","Mean degree value of the structural contacting neighbors for a given residue"]
["Physicochemical Properties of the Structural Contacting Neighbors"]
[156,"NB_MeanF1","Mean factor Ⅰ solution score of the contacting neighbors"]
[157,"dF1_Mean_Mutant","Difference between factor Ⅰ solution score of neighbors'mean value and mutant amino acid"]
[158,"varF1_Wild_NB","Variance of factor Ⅰ solution scores for the wild-type amino acid and its neighbors"]
[159,"varF1_Mutant_NB","Variance of factor Ⅰ solution scores for the mutant amino acid and its neighbors"]
[160,"dVarF1","Change of variance of factor Ⅰ solution score by the AAS"]
[161,"NB_MeanF2","Mean factor Ⅱ solution score of the contacting neighbors"]
[162,"dF2_Mean_Mutant","Difference between factor Ⅱ solution score of neighbors' mean value and mutant amino acid"]
[163,"varF2_Wild_NB","Variance of factor Ⅱ solution scores for the wild-type amino acid and its neighbors"]
[164,"varF2_Mutant_NB","Variance of factor Ⅱ solution scores for the mutant amino acid and its neighbors"]
[165,"dVarF2","Change of variance of factor Ⅱ solution score by the AAS"]
[166,"NB_MeanF3","Mean factor Ⅲ solution score of the contacting neighbors"]
[167,"dF3_Mean_Mutant","Difference between factor Ⅲ solution score of neighbors' mean value and mutant amino acid"]
[168,"varF3_Wild_NB","Variance of factor Ⅲ solution scores for the wild-type amino acid and its neighbors"]
[169,"varF3_Mutant_NB","Variance of factor Ⅲ solution scores for the mutant amino acid and its neighbors"]
[170,"dVarF3","Change of variance of factor Ⅲ solution score by the AAS"]
[171,"NB_MeanF4","Mean factor Ⅳ solution score of the contacting neighbors"]
[172,"dF4_Mean_Mutant","Difference between factor Ⅳ solution score of neighbors' mean value and mutant amino acid"]
[173,"varF4_Wild_NB","Variance of factor Ⅳ solution scores for the wild-type amino acid and its neighbors"]
[174,"varF4_Mutant_NB","Variance of factor Ⅳ solution scores for the mutant amino acid and its neighbors"]
[175,"dVarF4","Change of variance of factor Ⅳ solution score by the AAS"]
[176,"NB_MeanF5","Mean factor Ⅴ solution score of the contacting neighbors"]
[177,"dF5_Mean_Mutant","Difference between factor Ⅴ solution score of neighbors' mean value and mutant amino acid"]
[178,"varF5_Wild_NB","Variance of factor Ⅴ solution scores for the wild-type amino acid and its neighbors"]
[179,"varF5_Mutant_NB","Variance of factor Ⅴ solution scores for the mutant amino acid and its neighbors"]
[180,"dVarF5","Change of variance of factor Ⅴ solution score by the AAS"]
[181,"NB_MeanVol","Mean Grantham molecular volume of the contacting neighbors"]
[182,"dVol_Mean_Mutant","Difference between Grantham molecular volume of neighbors' mean value and mutant amino acid"]
[183,"varVol_Wild_NB","Variance of Grantham molecular volume for the wild-type amino acid and its neighbors"]
[184,"varVol_Mutant_NB","Variance of Grantham molecular volume for the mutant amino acid and its neighbors"]
[185,"dVarVol","Change of variance of Grantham molecular volume by the AAS"]
[186,"NB_MeanHP","Mean Kyte-Doolittle hydropathy index of the contacting neighbors"]
[187,"dHP_Mean_Mutant","Difference between Kyte-Doolittle hydropathy index of neighbors' mean value and mutant amino acid"]
[188,"varHP_Wild_NB","Variance of Kyte-Doolittle hydropathy index for the wild-type amino acid and its neighbors"]
[189,"varHP_Mutant_NB","Variance of Kyte-Doolittle hydropathy index for the mutant amino acid and its neighbors"]
[190,"dVarHP","Change of variance of Kyte-Doolittle hydropathy index by the AAS"]
[191,"NB_MeanpI","Mean Isoelectric point of the contacting neighbors"]
[192,"dpI_Mean_Mutant","Difference between Isoelectric point of neighbors' mean value and mutant amino acid"]
[193,"varpI_Wild_NB","Variance of Isoelectric point for the wild-type amino acid and its neighbors"]
[194,"varpI_Mutant_NB","Variance of Isoelectric point for the mutant amino acid and its neighbors"]
[195,"dVarpI","Change of variance of Isoelectric point by the AAS"]
["Contact Energy"]
[196,"MJ1","The sum of (i.e. Total) residue contact energy between the wild-type residue and all its contacting neighbors derived from MIYS990106 (AAindex accession number) "]
[197,"dMJ1","Change of total residue contact energy by the AAS derived from MIYS990106"]
[198,"MJ2","The sum of (i.e. Total) residue contact energy between the wild-type residue and all its contacting neighbors derived from MIYS990107 (AAindex accession number) "]
[199,"dMJ2","Change of total residue contact energy by the AAS derived from MIYS990107"]
[200,"ERCE","The sum of (i.e. Total) Environment-dependent Residue Contact Energy between the wild-type residue and all its contacting neighbors derived from 6 matrices"]
[201,"dERCE","Change of total Environment-dependent Residue Contact Energy by the AAS"]
[202,"Abs_MJ1","Absolute total residue contact energy of the wild-type amino acid and its neighbors derived from MIYS990106 "]
[203,"Abs_dMJ1","Absolute change of total residue contact energy by the AAS derived from MIYS990106"]
[204,"Abs_MJ2","Absolute total residue contact energy of the wild-type amino acid and its neighbors derived from MIYS990107"]
[205,"Abs_dMJ2","Absolute change of total residue contact energy by the AAS derived from MIYS990107"]
[206,"Abs_ERCE","Absolute total Environment-dependent Residue Contact Energy of the wild-type amino acid and its neighbors derived from 6 matrices"]
[207,"Abs_dERCE","Absolute change of total Environment-dependent Residue Contact Energy by the AAS"]
["Other Structural Features"]
[208,"CDSS","Context-Dependent Substitution Score derived from 8 matrices"]
[209,"MIcomulative","The sum of corrected Mutual Information values for a residue with all its structural contacting neighbors computed by RING software"]
[210,"RSA","3D structure-based residue Relative Solvent Accessibility computed by NACCESS"]
[211,"N_Hbond","Number of hydrogen bonds annotated by HBPLUS"]
[212,"ΔΔG","Mutational free energy change, a measure of protein stability change, calculated by FoldX"]