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["TestDataset2 and the prediction results of AAS3D-RF, structure-removed, and seven other predictors1"]
["UniProt_AC","Gene","Structure_ID","AAS","Functional_Effect","daAAS_Ratio","nal_1e-45","Homologous_to_TrainDataset","SIFT_score","SIFT_prediction","PPH2_HD_score","PPH2_HD_prediction","PPH2_HV_score","PPH2_HV_prediction","PROVEAN_score","PROVEAN_prediction","FATHMM-W_score","FATHMM-W_prediction","FATHMM-U_score","FATHMM-U_prediction","PANTHER-PSEP_score","PANTHER-PSEP_prediction","AAS3D-RF_score","AAS3D-RF_prediction","structure-removed_score","structure-removed_prediction"]
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["Q9H2U2","PPA2","Q9H2U2_34_333","p.P167L","disease",0.889,3146,"N","0.00","1","1","1","1","1","-9.379","1","-1.14","-1","-7.27","1","4200","1","0.801128662266","1",0.833191603787,1]
["Q9H2U2","PPA2","Q9H2U2_34_333","p.E172K","disease",0.889,3146,"N","0.02","1","0.996","1","0.849","1","-3.691","1","0.85","-1","-2.50","-1","1237","1","0.739529366937","1",0.734378498296,1]
["Q9H2U2","PPA2","Q9H2U2_34_333","p.P228L","disease",0.889,3120,"N","0.00","1","1","1","0.997","1","-9.378","1","0.06","-1","-5.12","1","750","1","0.72971942998","1",0.832487980771,1]
["Q9H2U2","PPA2","Q9H2U2_34_333","p.Q294P","disease",0.889,2854,"N","0.02","1","0.43","-1","0.157","-1","-3.044","1","0.98","-1","-1.63","-1","91","-1","0.565811559755","1",0.430224246729,-1]
["P46059","SLC15A1","P46059_391_578","p.G419A","neutral",0,2772,"N","0.67","-1","0","-1","0.001","-1","-0.209","-1","3.38","-1","-2.15","-1","30","-1","0.0931870842958","-1",0.0846929522381,-1]
["P46059","SLC15A1","P46059_391_578","p.T451N","neutral",0,2616,"N","0.45","-1","0","-1","0.008","-1","-2.637","1","3.62","-1","-1.79","-1","176","-1","0.0788151142027","-1",0.106027800851,-1]
["P46059","SLC15A1","P46059_391_578","p.V450I","neutral",0,2618,"N","0.38","-1","0.002","-1","0.008","-1","-0.787","-1","3.59","-1","-1.32","-1","176","-1","0.0894361847408","-1",0.100855144432,-1]
["P46059","SLC15A1","P46059_391_578","p.R459C","neutral",0,2601,"N","0.08","-1","1","1","0.993","1","-7.803","1","3.65","-1","-1.22","-1","97","-1","0.362228849377","-1",0.401429414526,-1]
["P46059","SLC15A1","P46059_391_578","p.P537S","neutral",0,2522,"N","0.74","-1","0.002","-1","0.007","-1","-1.208","-1","4.59","-1","1.04","-1","97","-1","0.070150097259","-1",0.0547351028172,-1]
["Q99612","KLF6","Q99612_178_282","p.S180L","neutral",0,2066,"Y","0.18","-1","0","-1","0","-1","-1.894","-1","2.73","-1","-3.45","1","91","-1","0.126259241777","-1",0.154104907551,-1]
["Q00005","PPP2R2B","Q00005_7_442","p.G36V","neutral",0.5,2637,"N","0.00","1","1","1","1","1","-6.940","1","0.99","-1","-9.72","1","1628","1","0.928246937321","1",0.867864287563,1]
["Q00005","PPP2R2B","Q00005_7_442","p.R138P","disease",0.5,2943,"N","0.30","-1","0.007","-1","0.009","-1","-3.501","1","-0.83","-1","-1.67","-1","797","1","0.395773314354","-1",0.407067524147,-1]
["Q2TB90","HKDC1","Q2TB90_1_910","p.D54G","neutral",0,3379,"Y","0.03","1","0.051","-1","0.008","-1","-5.164","1","-5.34","1","-1.00","-1","91","-1","0.144064903931","-1",0.164790104164,-1]
["Q2TB90","HKDC1","Q2TB90_1_910","p.T124I","neutral",0,3541,"Y","0.06","-1","0","-1","0.002","-1","-3.469","1","-5.36","1","-2.17","-1","1","-1","0.159027160189","-1",0.144755930119,-1]
["Q2TB90","HKDC1","Q2TB90_1_910","p.L204P","neutral",0,3668,"Y","0.00","1","0.896","1","0.457","-1","-4.656","1","-4.87","1","-2.26","-1","1","-1","0.655936549092","1",0.548514003284,1]
["Q2TB90","HKDC1","Q2TB90_1_910","p.W721R","neutral",0,3896,"Y","0.42","-1","0","-1","0","-1","5.877","-1","-3.65","1","5.55","-1","1","-1","0.0527644530455","-1",0.042148114908,-1]
["Q99500","S1PR3","Q99500_21_313","p.R243Q","neutral",0,2695,"Y","0.01","1","1","1","0.998","1","-2.816","1","1.07","-1","-2.58","-1","750","1","0.2597176329","-1",0.333502584236,-1]
["P29120","PCSK1","P29120_31_103","p.R80Q","neutral",0.5,2887,"N","0.07","-1","0.995","1","0.56","1","-2.611","1","1.50","-1","-1.22","-1","455","1","0.336357654078","-1",0.323051924587,-1]
["Q14683","SMC1A","Q14683_1074_1223","p.Y1085C","disease",1,2905,"N","-","-","1","1","1","1","-7.979","1","-1.48","-1","-5.62","1","750","1","0.890792425782","1",0.900665799012,1]
["Q14683","SMC1A","Q14683_1074_1223","p.F1122L","disease",1,2856,"N","-","-","1","1","1","1","-4.909","1","-2.71","1","-0.54","-1","750","1","0.779174183515","1",0.842086191046,1]
["Q14683","SMC1A","Q14683_1074_1223","p.R1123W","disease",1,2856,"N","-","-","0.995","1","0.79","1","-4.321","1","-2.99","1","-6.64","1","750","1","0.74679999365","1",0.779725985078,1]
["O60229","KALRN","O60229_1279_1583","p.E1326D","neutral",0,3106,"Y","-","-","0.321","-1","0.645","1","-2.500","1","-0.02","-1","-0.63","-1","750","1","0.679149907904","1",0.709374772831,1]
["Q9H082","RAB33B","Q9H082_32_196","p.K46Q","disease",1,2501,"Y","0.00","1","1","1","1","1","-3.384","1","-4.16","1","-9.02","1","4200","1","0.872035822213","1",0.85180209773,1]
["Q9H082","RAB33B","Q9H082_32_196","p.N148K","disease",1,2560,"Y","0.00","1","1","1","0.981","1","-5.986","1","-2.35","1","-6.08","1","4200","1","0.878206343179","1",0.858183911274,1]
["Q9NRH3","TUBG2","Q9NRH3_2_446","p.M413V","neutral",0,3011,"N","0.13","-1","0","-1","0","-1","-1.608","-1","-1.93","1","-1.87","-1","-","-","0.507310103628","1",0.53029807759,1]
["P30492","HLA-B","P30492_25_309","p.Y33H","neutral",0,3106,"Y","0.44","-1","0.003","-1","0.032","-1","-0.778","-1","9.29","-1","-2.47","-1","-","-","0.00205242534848","-1",1.56406069109E-3,-1]
["P30492","HLA-B","P30492_25_309","p.N87D","neutral",0,3151,"Y","0.02","1","0.3","-1","0.335","-1","0.294","-1","5.86","-1","0.42","-1","-","-","0.014315469802","-1",0.00412321730023,-1]
["P30492","HLA-B","P30492_25_309","p.T97A","neutral",0,3151,"Y","0.10","-1","0.242","-1","0.278","-1","-2.202","-1","9.42","-1","-0.87","-1","176","-1","0.000540625669463","-1",0.000766109966206,-1]
["P30492","HLA-B","P30492_25_309","p.S101N","neutral",0,3151,"Y","1.00","-1","0","-1","0.003","-1","1.290","-1","5.85","-1","1.35","-1","-","-","0.000929899530652","-1",0.000534477819561,-1]
["P30492","HLA-B","P30492_25_309","p.N87K","neutral",0,3151,"Y","0.02","1","0.842","1","0.559","1","-0.266","-1","5.81","-1","-0.14","-1","-","-","0.00461704422741","-1",1.34894049477E-3,-1]
["P30492","HLA-B","P30492_25_309","p.D98Y","neutral",0,3151,"Y","0.64","-1","0.003","-1","0.009","-1","0.964","-1","9.52","-1","1.05","-1","-","-","0.00154535609445","-1",0.000790447450488,-1]
["Q9NRV9","HEBP1","Q9NRV9_1_189","p.E183D","neutral",0,1966,"N","0.00","1","0.995","1","0.994","1","-2.585","1","-0.41","-1","-7.09","1","750","1","0.755374840593","1",0.6766357154,1]
["P35556","FBN2","P35556_1114_1199","p.D1115H","disease",0.909,17882,"Y","-","-","1","1","0.998","1","-6.556","1","-5.39","1","-9.50","1","-","-","0.868834967022","1",0.920485304655,1]
["P35556","FBN2","P35556_1114_1199","p.C1142F","disease",0.909,18027,"Y","-","-","0.997","1","0.996","1","-10.362","1","-5.91","1","-10.67","1","-","-","0.910488574499","1",0.91077456298,1]
["P35556","FBN2","P35556_1114_1199","p.G1179C","disease",0.909,18087,"Y","-","-","1","1","0.992","1","-8.789","1","-6.16","1","-11.31","1","-","-","0.879519012556","1",0.881455119558,1]
["P35556","FBN2","P35556_1114_1199","p.C1198Y","disease",0.909,18109,"Y","-","-","0.99","1","0.925","1","-10.741","1","-7.98","1","-17.65","1","-","-","0.936649660044","1",0.932898444455,1]
["P35556","FBN2","P35556_1114_1199","p.S1122P","disease",0.909,17971,"Y","-","-","0.997","1","0.995","1","-4.710","1","-2.90","1","-2.73","-1","-","-","0.784304843305","1",0.786559754863,1]
["P35556","FBN2","P35556_1114_1199","p.C1142R","disease",0.909,18027,"Y","-","-","0.997","1","0.996","1","-11.303","1","-5.91","1","-10.50","1","-","-","0.907040631577","1",0.932407563769,1]
["P35556","FBN2","P35556_1114_1199","p.Y1146C","disease",0.909,18018,"Y","-","-","0.993","1","0.89","1","-8.447","1","-3.77","1","-7.53","1","-","-","0.849894226103","1",0.867752505503,1]
["P35556","FBN2","P35556_1114_1199","p.C1156F","disease",0.909,17967,"Y","-","-","0.997","1","0.996","1","-10.360","1","-2.77","1","-4.50","1","-","-","0.887153643962","1",0.892649980947,1]
["P35556","FBN2","P35556_1114_1199","p.E1161K","disease",0.909,18032,"Y","-","-","0.999","1","0.993","1","-3.904","1","-5.18","1","-7.69","1","-","-","0.803472186587","1",0.847145533894,1]
["P35556","FBN2","P35556_1114_1199","p.E1144K","disease",0.909,18030,"Y","-","-","0.799","1","0.298","-1","-3.241","1","-3.02","1","-0.53","-1","-","-","0.560893754867","1",0.579986869144,1]
["P62736","ACTA2","P62736_3_377","p.T196S","neutral",0.833,3254,"Y","0.10","-1","0.018","-1","0.256","-1","-2.488","-1","-3.27","1","1.10","-1","910","1","0.353205314897","-1",0.405624572456,-1]
["P62736","ACTA2","P62736_3_377","p.T320A","neutral",0.833,3049,"Y","0.11","-1","0","-1","0.002","-1","-3.346","1","-3.35","1","-0.72","-1","842","1","0.335308644655","-1",0.41323410669,-1]
["P62736","ACTA2","P62736_3_377","p.H373P","neutral",0.833,2272,"Y","0.00","1","0.002","-1","0.116","-1","-4.586","1","-3.50","1","-2.71","-1","910","1","0.877001488495","1",0.86537699855,1]
["P62736","ACTA2","P62736_3_377","p.N117T","disease",0.833,3226,"Y","0.00","1","0.297","-1","0.704","1","-4.806","1","-4.36","1","-2.10","-1","910","1","0.89524133697","1",0.918470709936,1]
["P62736","ACTA2","P62736_3_377","p.R118Q","disease",0.833,3226,"Y","0.01","1","0.768","1","0.733","1","-3.152","1","-4.05","1","-2.40","-1","910","1","0.785034235807","1",0.695727529378,1]
["P62736","ACTA2","P62736_3_377","p.Y135H","disease",0.833,3259,"Y","0.01","1","0.967","1","0.981","1","-4.414","1","-3.61","1","-3.17","1","910","1","0.794801520206","1",0.732615002598,1]
["P62736","ACTA2","P62736_3_377","p.R149C","disease",0.833,3262,"Y","0.02","1","0.999","1","0.979","1","-7.194","1","-4.96","1","-7.01","1","910","1","0.87492048319","1",0.827570649142,1]
["P62736","ACTA2","P62736_3_377","p.V154A","disease",0.833,3261,"Y","0.00","1","0.999","1","1","1","-3.629","1","-5.61","1","-4.74","1","910","1","0.714967370345","1",0.783298344778,1]
["P62736","ACTA2","P62736_3_377","p.R258C","disease",0.833,3244,"Y","0.04","1","0.998","1","0.981","1","-6.784","1","-3.58","1","-5.07","1","910","1","0.869457815671","1",0.82855796191,1]
["P62736","ACTA2","P62736_3_377","p.R258H","disease",0.833,3244,"Y","0.00","1","0.994","1","0.959","1","-4.340","1","-3.55","1","-3.20","1","910","1","0.813499624167","1",0.765671327578,1]
["P62736","ACTA2","P62736_3_377","p.R292G","disease",0.833,3162,"Y","0.00","1","0.941","1","0.954","1","-5.774","1","-3.87","1","-4.61","1","910","1","0.824778989509","1",0.879497960736,1]
["P62736","ACTA2","P62736_3_377","p.T353N","disease",0.833,2754,"Y","0.00","1","0.54","1","0.935","1","-3.065","1","-3.53","1","-1.84","-1","910","1","0.832174921748","1",0.830360679354,1]
["P62736","ACTA2","P62736_3_377","p.R39H","disease",0.833,2678,"Y","0.07","-1","0.017","-1","0.05","-1","-2.662","1","-2.96","1","-4.09","1","910","1","0.584237340439","1",0.58445636902,1]
["P62736","ACTA2","P62736_3_377","p.Y145C","disease",0.833,3262,"Y","0.01","1","0.924","1","0.967","1","-8.143","1","-4.03","1","-7.17","1","910","1","0.812519499466","1",0.839131656729,1]
["P62736","ACTA2","P62736_3_377","p.R185Q","disease",0.833,3252,"Y","0.00","1","1","1","1","1","-3.599","1","-3.44","1","-1.63","-1","910","1","0.803296127219","1",0.798387301355,1]
["P62736","ACTA2","P62736_3_377","p.R212Q","disease",0.833,3255,"Y","0.00","1","1","1","1","1","-3.633","1","-4.43","1","-0.56","-1","910","1","0.768519632941","1",0.795348163813,1]
["P62736","ACTA2","P62736_3_377","p.T326N","disease",0.833,3015,"Y","0.08","-1","0.004","-1","0.351","-1","-2.326","-1","-3.41","1","-0.19","-1","910","1","0.387943795369","-1",0.42457203186,-1]
["P62736","ACTA2","P62736_3_377","p.R179H","disease",0.833,3255,"Y","0.02","1","0.15","-1","0.18","-1","-4.520","1","-3.57","1","-2.39","-1","910","1","0.700633668611","1",0.750830551813,1]
["Q02386","ZNF45","Q02386_285_438","p.T299A","neutral",0,15762,"Y","0.04","1","0.001","-1","0.004","-1","-2.232","-1","1.73","-1","-5.59","1","53","-1","0.430244645023","-1",0.449167687203,-1]
["Q02386","ZNF45","Q02386_285_438","p.P303R","neutral",0,15735,"Y","0.02","1","1","1","1","1","-7.380","1","2.29","-1","-5.01","1","53","-1","0.502476975872","1",0.521128358187,1]
[]
["1Column descriptions"]
["Column","Description"]
["UniProt_AC"," The UniProt accession number of each protein sequence."]
["Structure_ID"," It is the same as provided in \"List of homology model structures.xlsx\". "]
["Functional_Effect","The true classification of each AAS."]
["daAAS_Ratio","The ratio of daAAS number in its source protein."]
["nal_1e-45","The feature that represents the number of homologous sequence hits in database search with E-value of 1e-45."]
["Homologous_to_TrainDataset","Whether this AAS's protein has homologous sequence in TrainDataset with sequence identity >= 30%. "]
["Succeeding columns","The prediction results of each predictor, in the form of score and binary classification, with 1 denoting “disease” and -1 denoting “neutral”."]